When serum uric acid level increases beyond normal level it get deposited in joints where it get precipitated to form needle shaped uric acid crystals. These crystals can activate the immune system to produce a large number of chemical mediators known as cytokines and chemokines. These mediators in term cause inflammation and swelling and severe pain in the joints. This is called as “Gout”. Uric acid crystals may also get deposited below the skin as visible swelling known as “Tophi” which may cause ulcer releasing whitish chalky material of uric acid crystals. In long term if more uric will be produced it also can get deposited in kidney to cause kidney stone and kidney failure. This also may increase the risk of heart attack.